ZFIN ID: ZDB-PUB-181114-32
Sprouting and anastomosis in the Drosophila trachea and the vertebrate vasculature: Similarities and differences in cell behaviour
Kotini, M.P., Mäe, M.A., Belting, H.G., Betsholtz, C., Affolter, M.
Date: 2018
Source: Vascular Pharmacology   112: 8-16 (Journal)
Registered Authors: Affolter, Markus, Belting, Heinz-Georg Paul (Henry), Betsholtz, Christer
Keywords: Angiogenesis, Cell junctions, Development, Drosophila, Mouse, Vasculature, Zebrafish
MeSH Terms:
  • Animals
  • Blood Vessels/cytology*
  • Blood Vessels/metabolism
  • Cell Communication
  • Cell Differentiation
  • Cell Movement
  • Cell Proliferation
  • Cell Shape
  • Drosophila/cytology*
  • Drosophila/metabolism
  • Endothelial Cells/cytology*
  • Endothelial Cells/metabolism
  • Epithelial Cells/cytology*
  • Epithelial Cells/metabolism
  • Mice
  • Morphogenesis
  • Neovascularization, Physiologic*
  • Phenotype
  • Signal Transduction
  • Trachea/cytology*
  • Trachea/metabolism
  • Zebrafish/anatomy & histology*
  • Zebrafish/metabolism
PubMed: 30423447 Full text @ Vascul. Pharmacol.
ABSTRACT
Branching morphogenesis is a fascinating process whereby a simple network of biological tubes increases its complexity by adding new branches to existing ones, generating an enlarged structure of interconnected tubes. Branching morphogenesis has been studied extensively in animals and much has been learned about the regulation of branching at the cellular and molecular level. Here, we discuss studies of the Drosophila trachea and of the vertebrate vasculature, which have revealed how new branches are formed and connect (anastomose), leading to the establishment of complex tubular networks. We briefly describe the cell behaviour underlying tracheal and vascular branching. Although similar at many levels, the branching and anastomosis processes characterized thus far show a number of differences in cell behaviour, resulting in somewhat different tube architectures in these two organs. We describe the similarities and the differences and discuss them in the context of their possible developmental significance. We finish by highlighting some old and new data, which suggest that live imaging of the development of capillary beds in adult animals might reveal yet unexplored endothelial behaviour of endothelial cells.
ADDITIONAL INFORMATION