PUBLICATION
Understanding Central Nervous System Effects of Deliriant Hallucinogenic Drugs through Experimental Animal Models
- Authors
- Volgin, A.D., Yakovlev, O.A., Demin, K.A., Alekseeva, P.A., Kyzar, E.J., Collins, C., Nichols, D.E., Kalueff, A.V.
- ID
- ZDB-PUB-181023-1
- Date
- 2018
- Source
- ACS Chemical Neuroscience 10(1): 143-154 (Review)
- Registered Authors
- Kalueff, Allan V.
- Keywords
- Hallucinogens, antimuscarinic agents, deliriants, rodents, zebrafish
- MeSH Terms
-
- Animals
- Brain/drug effects*
- Brain/metabolism
- Central Nervous System Agents/pharmacology*
- Central Nervous System Agents/toxicity
- Delirium/chemically induced
- Delirium/metabolism
- Delirium/psychology
- Hallucinogens/pharmacology*
- Hallucinogens/toxicity
- Humans
- Models, Animal*
- Muscarinic Antagonists/pharmacology*
- Muscarinic Antagonists/toxicity
- PubMed
- 30252437 Full text @ ACS Chem. Neurosci.
Citation
Volgin, A.D., Yakovlev, O.A., Demin, K.A., Alekseeva, P.A., Kyzar, E.J., Collins, C., Nichols, D.E., Kalueff, A.V. (2018) Understanding Central Nervous System Effects of Deliriant Hallucinogenic Drugs through Experimental Animal Models. ACS Chemical Neuroscience. 10(1):143-154.
Abstract
Hallucinogenic drugs potently alter human behavior and have a millennia-long history of use for medicinal and religious purposes. Interest is rapidly growing in their potential as CNS modulators and therapeutic agents for brain conditions. Antimuscarinic cholinergic drugs, such as atropine and scopolamine, induce characteristic hyperactivity and dream-like hallucinations and form a separate group of hallucinogens known as "deliriants". Although atropine and scopolamine are relatively well-studied drugs in cholinergic physiology, deliriants represent the least-studied class of hallucinogens in terms of their behavioral and neurological phenotypes. As such, novel approaches and new model organisms are needed to investigate the CNS effects of these compounds. Here, we comprehensively evaluate the preclinical effects of deliriant hallucinogens in various animal models, their mechanisms of action, and potential interplay with other signaling pathways. We also parallel experimental and clinical findings on deliriant agents and outline future directions of translational research in this field.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping