ZFIN ID: ZDB-PUB-181020-16
Screening for drugs to reduce aggression in zebrafish
Norton, W.H.J.
Date: 2018
Source: Neuropharmacology   156: 107394 (Review)
Registered Authors: Norton, Will
Keywords: aggression, behaviour, drug screen, neural circuit, zebrafish
MeSH Terms:
  • Aggression/drug effects*
  • Animals
  • Behavior, Animal/drug effects
  • Brain/drug effects*
  • Drug Evaluation, Preclinical/methods*
  • Environmental Pollutants/toxicity
  • Models, Animal
  • Neurons
  • Zebrafish
PubMed: 30336150 Full text @ Neuropharmacology
Aggression is a common symptom of several human psychiatric disorders. However, the drugs available to treat aggression are non-specific and can have unwanted side effects. The zebrafish is an ideal model for behavioural pharmacology. They are small, aggression can be measured reliably, and drugs can be applied by immersion in the tank water. The ability to visualise and manipulate circuits in the intact brain represents an excellent opportunity to understand how chemical compounds modify the signalling pathways that control this behaviour. This review discusses protocols to measure zebrafish aggression, the neural circuits that control this behaviour and how pharmacological studies can inform us about environmental toxicology and the development of therapeutic drugs for humans.