PUBLICATION
Rational design of a ratiometric two-photon fluorescent probe for real-time visualization of apoptosis
- Authors
- Huang, Y., Zhou, Q., Feng, Y., Zhang, W., Fang, G., Fang, M., Chen, M., Xu, C., Meng, X.
- ID
- ZDB-PUB-181003-1
- Date
- 2018
- Source
- Chemical communications (Cambridge, England) 54: 10495-10498 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Mitochondria/metabolism
- Reactive Oxygen Species/metabolism
- Fluorescent Dyes/chemical synthesis
- Fluorescent Dyes/chemistry
- Fluorescent Dyes/pharmacology*
- Fluorescent Dyes/toxicity
- Humans
- Isomerism
- Cysteine/analysis*
- Quantum Theory
- Platinum/chemistry
- Photons
- Carbazoles/chemical synthesis
- Carbazoles/chemistry
- Carbazoles/pharmacology*
- Carbazoles/toxicity
- HeLa Cells
- Apoptosis*
- Animals
- Zebrafish
- Microscopy, Fluorescence
- Models, Chemical
- Drug Design*
- PubMed
- 30159580 Full text @ Chem. Commun. (Camb.)
Citation
Huang, Y., Zhou, Q., Feng, Y., Zhang, W., Fang, G., Fang, M., Chen, M., Xu, C., Meng, X. (2018) Rational design of a ratiometric two-photon fluorescent probe for real-time visualization of apoptosis. Chemical communications (Cambridge, England). 54:10495-10498.
Abstract
A dialdehyde-functionalized ratiometric two-photon fluorescent probe (Mito-DCHO) based on a symmetric carbazole-containing two-dimensional ICT system was rationally designed for cysteine-specific detection in mitochondria, which was utilized for real-time assessing and dual-channel visualization of the early stage of apoptosis by monitoring mitochondrial oxidative stress levels.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping