ZFIN ID: ZDB-PUB-180921-17
Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes
Burguera, D., Marquez, Y., Racioppi, C., Permanyer, J., Torres-Méndez, A., Esposito, R., Albuixech-Crespo, B., Fanlo, L., D'Agostino, Y., Gohr, A., Navas-Perez, E., Riesgo, A., Cuomo, C., Benvenuto, G., Christiaen, L.A., Martí, E., D'Aniello, S., Spagnuolo, A., Ristoratore, F., Arnone, M.I., Garcia-Fernàndez, J., Irimia, M.
Date: 2017
Source: Nature communications   8: 1799 (Journal)
Registered Authors: D'Aniello, Salvatore, Esposito, Rosaria, Irimia, Manuel
Keywords: none
Microarrays: GEO:GSE97267
MeSH Terms:
  • Animals
  • Biological Evolution
  • CRISPR-Cas Systems
  • Embryonic Development/genetics*
  • Epithelial-Mesenchymal Transition/physiology*
  • Exons/physiology
  • Female
  • Gene Expression Regulation, Developmental/physiology
  • Gene Knockdown Techniques
  • Lancelets
  • Male
  • Mutation
  • RNA Splicing/physiology*
  • RNA-Binding Proteins/genetics
  • RNA-Binding Proteins/physiology*
  • Sequence Homology, Amino Acid
  • Signal Transduction/genetics
  • Strongylocentrotus purpuratus
  • Urochordata
  • Zebrafish
PubMed: 29180615 Full text @ Nat. Commun.
Epithelial-mesenchymal interactions are crucial for the development of numerous animal structures. Thus, unraveling how molecular tools are recruited in different lineages to control interplays between these tissues is key to understanding morphogenetic evolution. Here, we study Esrp genes, which regulate extensive splicing programs and are essential for mammalian organogenesis. We find that Esrp homologs have been independently recruited for the development of multiple structures across deuterostomes. Although Esrp is involved in a wide variety of ontogenetic processes, our results suggest ancient roles in non-neural ectoderm and regulating specific mesenchymal-to-epithelial transitions in deuterostome ancestors. However, consistent with the extensive rewiring of Esrp-dependent splicing programs between phyla, most developmental defects observed in vertebrate mutants are related to other types of morphogenetic processes. This is likely connected to the origin of an event in Fgfr, which was recruited as an Esrp target in stem chordates and subsequently co-opted into the development of many novel traits in vertebrates.