ZFIN ID: ZDB-PUB-180917-4
Goldfish: An old and new model system to study vertebrate development, evolution, and human disease
Omori, Y., Kon, T.
Date: 2018
Source: Journal of biochemistry   165(3): 209-218 (Review)
Registered Authors: Omori, Yoshihiro
Keywords: none
MeSH Terms:
  • Animals
  • Disease*/genetics
  • Disease Models, Animal
  • Goldfish/genetics
  • Goldfish/growth & development
  • Goldfish/physiology*
  • Humans
  • Models, Animal*
  • Phenotype
PubMed: 30219851 Full text @ J. Biochem.
The goldfish (Carassius auratus) is a domesticated cyprinid teleost closely related to the crucian carp. Goldfish domestication occurred in South China around 1,000 years ago. At least 180 variants and 70 genetically established strains are currently produced. These strains possess diverse phenotypes in body shape, coloration, scales, and fin, eye, and hood morphology. These include biologically interesting phenotypes that have not been observed in mutants of zebrafish or medaka. In addition, goldfish strains have been maintained in a non-wild environment for several hundreds of generations, and certain goldfish strains have phenotypes similar to some human diseases. The recent progress in the assembly of the whole genome sequence of goldfish provides strong tools for a genetic analysis of these phenotypes. The whole genome duplication (WGD) event occurred in the goldfish genome 8-14 million years ago; this is one of the latest WGD in vertebrates. Goldfish are a useful model for studying genome evolution after the WGD event. This review focuses on the potential for goldfish as a model system in understanding the molecular basis of vertebrate development and evolution and human diseases.