PUBLICATION
Zebrafish as a model for studying functional pancreatic β cells development and regeneration
- Authors
- Matsuda, H.
- ID
- ZDB-PUB-180823-9
- Date
- 2018
- Source
- Development, growth & differentiation 60: 393-399 (Review)
- Registered Authors
- Matsuda, Hiroki
- Keywords
- development, pancreas, pancreatic β cell, regeneration
- MeSH Terms
-
- Animals
- Humans
- Insulin-Secreting Cells/cytology
- Insulin-Secreting Cells/metabolism*
- Models, Biological*
- Regeneration/physiology*
- Zebrafish/metabolism*
- PubMed
- 30133710 Full text @ Dev. Growth Diff.
Citation
Matsuda, H. (2018) Zebrafish as a model for studying functional pancreatic β cells development and regeneration. Development, growth & differentiation. 60:393-399.
Abstract
Pancreatic β cells produce insulin and play a central role in glucose homeostasis. The regenerative capacity of mammalian β cells is limited, so that loss and dysfunction of β cells causes diabetes. Zebrafish have a pancreas which is functionally and morphologically conserved with human pancreas. Zebrafish have high regenerative capacity of islets. In the present review, development of zebrafish pancreas was described in comparison to that of mammals, and the regenerative process of zebrafish pancreas was also described. This review will give information on understanding islet and pancreatic β cell development and regeneration and provide possibilities of zebrafish research for developing new diabetic therapies and regenerative medicines.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping