ZFIN ID: ZDB-PUB-180710-8
Luminance Changes Drive Directional Startle through a Thalamic Pathway
Heap, L.A.L., Vanwalleghem, G., Thompson, A.W., Favre-Bulle, I.A., Scott, E.K.
Date: 2018
Source: Neuron   99(2): 293-301.e4 (Journal)
Registered Authors: Scott, Ethan, Thompson, Andrew W.
Keywords: GCaMP, SPIM, calcium imaging, selective plane illumination microscopy, superior colliculus, tectum, thalamus, vision, visual escape, zebrafish
MeSH Terms:
  • Animals
  • Animals, Genetically Modified
  • Escape Reaction/physiology*
  • Female
  • Male
  • Photic Stimulation/methods*
  • Reflex, Startle/physiology*
  • Superior Colliculi/chemistry
  • Superior Colliculi/physiology*
  • Thalamus/chemistry
  • Thalamus/physiology*
  • Visual Pathways/chemistry
  • Visual Pathways/physiology*
  • Zebrafish
PubMed: 29983325 Full text @ Neuron
FIGURES
ABSTRACT
Looming visual stimuli result in escape responses that are conserved from insects to humans. Despite their importance for survival, the circuits mediating visual startle have only recently been explored in vertebrates. Here we show that the zebrafish thalamus is a luminance detector critical to visual escape. Thalamic projection neurons deliver dim-specific information to the optic tectum, and ablations of these projections disrupt normal tectal responses to looms. Without this information, larvae are less likely to escape from dark looming stimuli and lose the ability to escape away from the source of the loom. Remarkably, when paired with an isoluminant loom stimulus to the opposite eye, dimming is sufficient to increase startle probability and to reverse the direction of the escape so that it is toward the loom. We suggest that bilateral comparisons of luminance, relayed from the thalamus to the tectum, facilitate escape responses and are essential for their directionality.
ADDITIONAL INFORMATION