PUBLICATION
Citrofulvicin, an Antiosteoporotic Polyketide from Penicillium velutinum
- Authors
- Chen, Y., Jiang, N., Wei, Y.J., Li, X., Ge, H.M., Jiao, R.H., Tan, R.X.
- ID
- ZDB-PUB-180622-40
- Date
- 2018
- Source
- Organic letters 20(13): 3741-3744 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Cycloaddition Reaction
- Molecular Structure
- Penicillium*
- Polyketides
- PubMed
- 29927257 Full text @ Org. Lett.
Citation
Chen, Y., Jiang, N., Wei, Y.J., Li, X., Ge, H.M., Jiao, R.H., Tan, R.X. (2018) Citrofulvicin, an Antiosteoporotic Polyketide from Penicillium velutinum. Organic letters. 20(13):3741-3744.
Abstract
Citrofulvicin (1), along with its early shunt product fulvionol (2), was characterized as a skeletally unprecedented antiosteoporotic agent from a human sputum-derived fungus Penicillium velutinum. The unique citrofulvicin framework is likely formed by a nonenzymatic intermolecular Diels-Alder cycloaddition between heptaketide-based intermediates. Citrofulvicin and fulvionol were demonstrated to be osteogenic at 0.1 μM in the prednisolone-induced osteoporotic zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping