PUBLICATION

Epigenetic and Epitranscriptomic Factors Make a Mark on Hematopoietic Stem Cell Development

Authors
Kasper, D.M., Nicoli, S.
ID
ZDB-PUB-180622-4
Date
2018
Source
Current stem cell reports   4: 22-32 (Review)
Registered Authors
Kasper, Dionna, Nicoli, Stefania
Keywords
HSC production, chromatin modification, endothelial to hematopoietic transition, hemogenic endothelium, m6A methylation, transdifferentiation
MeSH Terms
none
PubMed
29910999 Full text @ Curr Stem Cell Rep
Citation
Kasper, D.M., Nicoli, S. (2018) Epigenetic and Epitranscriptomic Factors Make a Mark on Hematopoietic Stem Cell Development. Current stem cell reports. 4:22-32.
Abstract
Purpose of the review Blood specification is a highly dynamic process, whereby committed hemogenic endothelial cells (ECs) progressively transdifferentiate into multipotent, self-renewing hematopoietic stem cells (HSCs). Massive changes in gene expression must occur to switch cell identity, however the factors that mediate such an effect were a mystery until recently. This review summarizes the higher-order mechanisms involved in endothelial to hematopoietic reprogramming identified thus far.
Recent findings Accumulating evidence from mouse and zebrafish studies reveal that numerous chromatin-modifying (epigenetic) and RNA-modifying (epitranscriptomic) factors are required for the formation of HSCs from hemogenic endothelium. These genes function throughout the endothelial-hematopoietic transition, suggesting a dynamic interplay between 'epi'-machineries.
Summary Epigenetic and epitranscriptomic regulation are key mechanisms for reshaping global EC gene expression patterns to those that support HSC production. Future studies that capture modification dynamics should bring us closer to a complete understanding of how HSCs transition from hemogenic endothelium at the molecular level.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
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