PUBLICATION
Graphene biointerfaces for optical stimulation of cells
- Authors
- Savchenko, A., Cherkas, V., Liu, C., Braun, G.B., Kleschevnikov, A., Miller, Y.I., Molokanova, E.
- ID
- ZDB-PUB-180530-6
- Date
- 2018
- Source
- Science advances 4: eaat0351 (Journal)
- Registered Authors
- Miller, Yury
- Keywords
- none
- MeSH Terms
-
- Animals
- Biophysical Phenomena
- Cells, Cultured
- Graphite/chemistry*
- Hydrogen-Ion Concentration
- Light
- Myocytes, Cardiac/physiology*
- Myocytes, Cardiac/radiation effects*
- Nanostructures*
- Photic Stimulation*
- Rats
- Temperature
- Zebrafish
- PubMed
- 29795786 Full text @ Sci Adv
Citation
Savchenko, A., Cherkas, V., Liu, C., Braun, G.B., Kleschevnikov, A., Miller, Y.I., Molokanova, E. (2018) Graphene biointerfaces for optical stimulation of cells. Science advances. 4:eaat0351.
Abstract
Noninvasive stimulation of cells is crucial for the accurate examination and control of their function both at the cellular and the system levels. To address this need, we present a pioneering optical stimulation platform that does not require genetic modification of cells but instead capitalizes on unique optoelectronic properties of graphene, including its ability to efficiently convert light into electricity. We report the first studies of optical stimulation of cardiomyocytes via graphene-based biointerfaces (G-biointerfaces) in substrate-based and dispersible configurations. The efficiency of stimulation via G-biointerfaces is independent of light wavelength but can be tuned by changing the light intensity. We demonstrate that an all-optical evaluation of use-dependent drug effects in vitro can be enabled using substrate-based G-biointerfaces. Furthermore, using dispersible G-biointerfaces in vivo, we perform optical modulation of the heart activity in zebrafish embryos. Our discovery is expected to empower numerous fundamental and translational biomedical studies.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping