PUBLICATION
Zebrafish heart failure models: opportunities and challenges
- Authors
- Shi, X., Chen, R., Zhang, Y., Yun, J., Brand-Arzamendi, K., Liu, X., Wen, X.Y.
- ID
- ZDB-PUB-180508-5
- Date
- 2018
- Source
- Amino Acids 50(7): 787-798 (Review)
- Registered Authors
- Wen, Xiao-Yan
- Keywords
- Cardiomyopathy, Chemical compound, Heart failure, Mitochondria, Sarcomere, Zebrafish
- MeSH Terms
-
- Animals
- Cardiomyopathies*/genetics
- Cardiomyopathies*/metabolism
- Cardiomyopathies*/pathology
- Cardiomyopathies*/physiopathology
- Disease Models, Animal
- Heart Failure*/genetics
- Heart Failure*/metabolism
- Heart Failure*/pathology
- Heart Failure*/physiopathology
- Myocardium*/metabolism
- Myocardium*/pathology
- Zebrafish*/genetics
- Zebrafish*/metabolism
- PubMed
- 29725858 Full text @ Amino Acids
Citation
Shi, X., Chen, R., Zhang, Y., Yun, J., Brand-Arzamendi, K., Liu, X., Wen, X.Y. (2018) Zebrafish heart failure models: opportunities and challenges. Amino Acids. 50(7):787-798.
Abstract
Heart failure is a complex pathophysiological syndrome of pumping functional failure that results from injury, infection or toxin-induced damage on the myocardium, as well as genetic influence. Gene mutations associated with cardiomyopathies can lead to various pathologies of heart failure. In recent years, zebrafish, Danio rerio, has emerged as an excellent model to study human cardiovascular diseases such as congenital heart defects, cardiomyopathy, and preclinical development of drugs targeting these diseases. In this review, we will first summarize zebrafish genetic models of heart failure arose from cardiomyopathy, which is caused by mutations in sarcomere, calcium or mitochondrial-associated genes. Moreover, we outline zebrafish heart failure models triggered by chemical compounds. Elucidation of these models will improve the understanding of the mechanism of pathogenesis and provide potential targets for novel therapies.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping