PUBLICATION
Inhibition of drug-induced seizure development in both zebrafish and mouse models by a synthetic nanoreceptor
- Authors
- Huang, Q., Kuok, K.I., Zhang, X., Yue, L., Lee, S.M.Y., Zhang, J., Wang, R.
- ID
- ZDB-PUB-180503-3
- Date
- 2018
- Source
- Nanoscale 10(22): 10333-10336 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Animals
- Bridged-Ring Compounds/pharmacology*
- Disease Models, Animal
- Imidazoles/pharmacology*
- Larva
- Mice
- Mice, Inbred C57BL
- Molecular Structure
- Neuroprotective Agents/pharmacology*
- Pentylenetetrazole/adverse effects
- Seizures/chemically induced
- Seizures/drug therapy*
- Zebrafish
- PubMed
- 29717743 Full text @ Nanoscale
Citation
Huang, Q., Kuok, K.I., Zhang, X., Yue, L., Lee, S.M.Y., Zhang, J., Wang, R. (2018) Inhibition of drug-induced seizure development in both zebrafish and mouse models by a synthetic nanoreceptor. Nanoscale. 10(22):10333-10336.
Abstract
A synthetic nanoreceptor, cucurbit[7]uril (CB[7]), fully encapsulated pentylenetetrazol (PTZ), a seizure-inducing model drug. As a consequence of the encapsulation, the development of PTZ induced convulsion behaviors in both larval zebrafish and mouse models were dramatically alleviated, suggesting that CB[7] holds great neuroprotection potential against neurotoxic drugs for clinical applications.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping