PUBLICATION
Active mechanosensory feedback during locomotion in the zebrafish spinal cord
- Authors
- Knafo, S., Wyart, C.
- ID
- ZDB-PUB-180502-2
- Date
- 2018
- Source
- Current opinion in neurobiology 52: 48-53 (Other)
- Registered Authors
- Wyart, Claire
- Keywords
- none
- MeSH Terms
-
- Animals
- Feedback, Physiological/physiology*
- Interneurons/physiology*
- Locomotion/physiology*
- Mechanoreceptors/physiology*
- Motor Neurons/physiology*
- Spinal Cord/physiology*
- Zebrafish/physiology*
- PubMed
- 29704750 Full text @ Curr. Opin. Neurobiol.
Citation
Knafo, S., Wyart, C. (2018) Active mechanosensory feedback during locomotion in the zebrafish spinal cord. Current opinion in neurobiology. 52:48-53.
Abstract
The investigation of mechanosensory feedback to locomotion has been hindered by the challenge of recording neurons in motion. Genetic accessibility and optical transparency of zebrafish larvae provide means to revisit this question. Glutamatergic Rohon-Beard (RB) and GABAergic CSF-contacting neurons (CSF-cNs) are spinal mechanosensory neurons. Recent studies combining bioluminescence, silencing and optogenetic activation show that mechanosensory neurons enhance speed and stabilize posture during locomotion. RB neurons can modulate speed by projecting onto glutamatergic premotor V2a interneurons during fast swimming, while CSF-cNs inhibit V0-v interneurons sustaining slow swimming. Sensory gating, either through inhibition of sensory interneurons (CoPA) or though the direct inhibition of primary motor neurons by CSF-cNs, mediates postural control. Advanced optical methods have shed light on the dynamics of sensorimotor integration during active locomotion unraveling implications for translational research.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping