PUBLICATION
Acaulins A and B, Trimeric Macrodiolides from Acaulium sp. H-JQSF
- Authors
- Wang, T.T., Wei, Y.J., Ge, H.M., Jiao, R.H., Tan, R.X.
- ID
- ZDB-PUB-180407-2
- Date
- 2018
- Source
- Organic letters 20(8): 2490-2493 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
- none
- PubMed
- 29624065 Full text @ Org. Lett.
Citation
Wang, T.T., Wei, Y.J., Ge, H.M., Jiao, R.H., Tan, R.X. (2018) Acaulins A and B, Trimeric Macrodiolides from Acaulium sp. H-JQSF. Organic letters. 20(8):2490-2493.
Abstract
Acaulin A (1) and its macrolactone ring-opened congener acaulin B (2) were characterized from the culture of Acaulium sp. H-JQSF (an isopod-associated fungus) as architecturally undescribed trimeric macrodiolides, with the former being antiosteoporotic at 0.4 μM in the prednisolone-induced osteoporotic zebrafish. Identification of acaudiolic acid (3) as the monomeric macrodiolide precursor facilitated the proposal of the acaulin biosynthetic pathway.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping