PUBLICATION
Movement maintains forebrain neurogenesis via peripheral neural feedback in larval zebrafish
- Authors
- Hall, Z.J., Tropepe, V.
- ID
- ZDB-PUB-180313-5
- Date
- 2018
- Source
- eLIFE 7: (Journal)
- Registered Authors
- Tropepe, Vincent
- Keywords
- brain, developmental biology, dorsal root ganglia, motor experience, neural stem cell, neurogenesis, neuroscience, stem cells, zebrafish
- MeSH Terms
-
- Prosencephalon/growth & development*
- Cell Differentiation/genetics
- Larva/genetics
- Larva/growth & development
- Humans
- Movement/physiology
- Neurons/metabolism
- Neurons/physiology*
- Peripheral Nerves/growth & development
- Zebrafish/genetics
- Zebrafish/growth & development
- Animals
- Ganglia, Spinal/growth & development*
- Feedback, Sensory/physiology*
- Neurogenesis/genetics*
- PubMed
- 29528285 Full text @ Elife
Citation
Hall, Z.J., Tropepe, V. (2018) Movement maintains forebrain neurogenesis via peripheral neural feedback in larval zebrafish. eLIFE. 7.
Abstract
The postembryonic brain exhibits experience-dependent development, in which sensory experience guides normal brain growth. This neuroplasticity is thought to occur primarily through structural and functional changes in pre-existing neurons. Whether neurogenesis also mediates the effects of experience on brain growth is unclear. Here, we characterized the importance of motor experience on postembryonic neurogenesis in larval zebrafish. We found that movement maintains an expanded pool of forebrain neural precursors by promoting progenitor self-renewal over the production of neurons. Physical cues associated with swimming (bodily movement) increase neurogenesis and these cues appear to be conveyed by dorsal root ganglia (DRG) in the zebrafish body: DRG-deficient larvae exhibit attenuated neurogenic responses to movement and targeted photoactivation of DRG in immobilized larvae expands the pallial pool of proliferative cells. Our results demonstrate the importance of movement in neurogenic brain growth and reveal a fundamental sensorimotor association that may couple early motor and brain development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping