PUBLICATION
High-Frequency Echocardiography - Transformative Clinical and Research Applications in Humans, Mice, and Zebrafish
- Authors
- Wang, L.W., Kesteven, S.H., Huttner, I.G., Feneley, M.P., Fatkin, D.
- ID
- ZDB-PUB-180209-1
- Date
- 2018
- Source
- Circulation journal : official journal of the Japanese Circulation Society 82(3): 620-628 (Review)
- Registered Authors
- Fatkin, Diane
- Keywords
- Cardiac function, Echocardiography, Humans, Mice, Zebrafish
- MeSH Terms
-
- Animals
- Diagnostic Imaging/methods
- Echocardiography/instrumentation
- Echocardiography/methods
- Echocardiography/trends*
- Echocardiography, Doppler, Pulsed
- Heart/diagnostic imaging
- Humans
- Mice
- Research/instrumentation
- Research/trends
- Zebrafish
- PubMed
- 29415914 Full text @ Circ. J.
Citation
Wang, L.W., Kesteven, S.H., Huttner, I.G., Feneley, M.P., Fatkin, D. (2018) High-Frequency Echocardiography - Transformative Clinical and Research Applications in Humans, Mice, and Zebrafish. Circulation journal : official journal of the Japanese Circulation Society. 82(3):620-628.
Abstract
Echocardiography is an invaluable tool for characterizing cardiac structure and function in vivo. Technological advances in high-frequency ultrasound over the past 3 decades have increased spatial and temporal resolution, and facilitated many important clinical and basic science discoveries. Successful reverse translation of established echocardiographic techniques, including M-mode, B-mode, color Doppler, pulsed-wave Doppler, tissue Doppler and, most recently, myocardial deformation imaging, from clinical cardiology into the basic science laboratory has enabled researchers to achieve a deeper understanding of myocardial phenotypes in health and disease. With high-frequency echocardiography, detailed evaluation of ventricular systolic function in a range of small animal models is now possible. Furthermore, improvements in frame rate and the advent of diastolic strain rate imaging, when coupled with the use of select pulsed-wave Doppler parameters, such as isovolumic relaxation time and E wave deceleration, have enabled nuanced interpretation of ventricular diastolic function. Comparing pulsed-wave Doppler indices of atrioventricular inflow during early and late diastole with parameters that describe the simultaneous myocardial deformation (e.g., tissue Doppler é and á, global longitudinal strain rate and global longitudinal velocity) may yield additional insights related to myocardial compliance. This review will provide a historical perspective of the development of high-frequency echocardiography and consider how ongoing innovation will help future-proof this important imaging modality for 21st century translational research.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping