PUBLICATION
The role of macrophages during acute kidney injury: destruction and repair
- Authors
- Han, H.I., Skvarca, L.B., Espiritu, E.B., Davidson, A.J., Hukriede, N.A.
- ID
- ZDB-PUB-180201-6
- Date
- 2018
- Source
- Pediatric nephrology (Berlin, Germany) 34(4): 561-569 (Review)
- Registered Authors
- Davidson, Alan, Hukriede, Neil
- Keywords
- AKI, Macrophage, Neutrophils, Polarization, Zebrafish
- MeSH Terms
-
- Acute Kidney Injury/immunology
- Acute Kidney Injury/metabolism
- Acute Kidney Injury/pathology*
- Acute Kidney Injury/physiopathology
- Adaptive Immunity
- Animals
- Cell Plasticity*
- Cytokines/metabolism
- Humans
- Immunity, Innate
- Inflammation Mediators/metabolism
- Kidney/immunology
- Kidney/metabolism
- Kidney/pathology*
- Kidney/physiopathology
- Macrophage Activation*
- Macrophages/immunology
- Macrophages/metabolism
- Macrophages/pathology*
- Phenotype
- Regeneration*
- Signal Transduction
- PubMed
- 29383444 Full text @ Pediatr. Nephrol.
Citation
Han, H.I., Skvarca, L.B., Espiritu, E.B., Davidson, A.J., Hukriede, N.A. (2018) The role of macrophages during acute kidney injury: destruction and repair. Pediatric nephrology (Berlin, Germany). 34(4):561-569.
Abstract
Acute kidney injury (AKI) is defined by a rapid decline in renal function. Regardless of the initial cause of injury, the influx of immune cells is a common theme during AKI. While an inflammatory response is critical for the initial control of injury, a prolonged response can negatively affect tissue repair. In this review, we focus on the role of macrophages, from early inflammation to resolution, during AKI. These cells serve as the innate defense system by phagocytosing cellular debris and pathogenic molecules and bridge communication with the adaptive immune system by acting as antigen-presenting cells and secreting cytokines. While many immune cells function to initiate inflammation, macrophages play a complex role throughout AKI. This complexity is driven by their functional plasticity: the ability to polarize from a "pro-inflammatory" phenotype to a "pro-reparative" phenotype. Importantly, experimental and translational studies indicate that macrophage polarization opens the possibility to generate novel therapeutics to promote repair during AKI. A thorough understanding of the biological roles these phagocytes play during both injury and repair is necessary to understand the limitations while furthering the therapeutic application.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping