PUBLICATION
The balancing roles of mechanical forces during left-right patterning and asymmetric morphogenesis
- Authors
- Ferreira, R.R., Vermot, J.
- ID
- ZDB-PUB-171228-5
- Date
- 2017
- Source
- Mechanisms of Development 144: 71-80 (Review)
- Registered Authors
- Ferreira, Rita, Vermot, Julien
- Keywords
- none
- MeSH Terms
-
- Actomyosin/genetics*
- Actomyosin/metabolism
- Animals
- Biomechanical Phenomena
- Body Patterning/genetics*
- Cell Adhesion
- Cell Differentiation
- Cell Movement
- Cell Polarity/genetics*
- Chick Embryo
- Chickens
- Cilia/metabolism
- Embryo, Mammalian
- Embryo, Nonmammalian
- Gene Expression Regulation, Developmental*
- Mechanotransduction, Cellular
- Mice
- Zebrafish/embryology
- PubMed
- 27825898 Full text @ Mech. Dev.
Citation
Ferreira, R.R., Vermot, J. (2017) The balancing roles of mechanical forces during left-right patterning and asymmetric morphogenesis. Mechanisms of Development. 144:71-80.
Abstract
Left-right patterning and asymmetric morphogenesis arise from a complex set of molecular and cellular interactions that are particularly dynamic and associated with mechanical forces. How do mechanical forces translate into tissular asymmetries? Are these forces asymmetrical de novo, or do they build up from pre-existing asymmetries? Advances in developmental genetics, live imaging and cell biology have recently shed light on the origins of mechanical forces generated at the cell scale and their implication in asymmetric patterning and morphogenesis is now emerging. Here we ask when and how, molecular asymmetries and mechanical forces contribute to left-right patterning and organ asymmetries.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping