PUBLICATION

Experience-Dependent Plasticity of Odor Representations in the Telencephalon of Zebrafish

Authors
Jacobson, G.A., Rupprecht, P., Friedrich, R.W.
ID
ZDB-PUB-171219-12
Date
2017
Source
Current biology : CB   28(1): 1-14.e3 (Journal)
Registered Authors
Friedrich, Rainer
Keywords
activity pattern, calcium, olfactory cortex, plasticity, zebrafish
MeSH Terms
  • Action Potentials
  • Animals
  • Female
  • Male
  • Neuronal Plasticity*
  • Neurons/physiology
  • Odorants*
  • Olfactory Bulb/physiology
  • Olfactory Perception/physiology*
  • Recognition, Psychology
  • Telencephalon/physiology*
  • Zebrafish/physiology*
PubMed
29249662 Full text @ Curr. Biol.
Abstract
Sensory systems balance stability and plasticity to optimize stimulus representations in dynamic environments. We studied these processes in the olfactory system of adult zebrafish. Activity patterns evoked by repeated odor stimulation were measured by multiphoton calcium imaging in the olfactory bulb (OB) and in telencephalic area Dp, the homolog of olfactory cortex. Whereas odor responses in the OB were highly reproducible, responses of Dp neurons adapted over trials and exhibited substantial variability that could be attributed to ongoing activity and to systematic changes in neuronal representations following each stimulus. An NMDA receptor antagonist did not affect the magnitude of odor responses but strongly reduced the variability and experience-dependent modification of odor responses in Dp. As a consequence, odor representations became stable over trials. These results demonstrate that odor representations in higher brain areas are continuously modified by experience, supporting the view that olfactory processing is inseparable from memory, even in the absence of reinforcement.
Genes / Markers
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Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes