PUBLICATION
Endogenous retinal neural stem cell reprogramming for neuronal regeneration
- Authors
- Madelaine, R., Mourrain, P.
- ID
- ZDB-PUB-171215-6
- Date
- 2017
- Source
- Neural regeneration research 12: 1765-1767 (Review)
- Registered Authors
- Madelaine, Romain, Mourrain, Philippe
- Keywords
- Mόller glial cells, Onecut, Tlx, achaete-scute homolog 1, microRNA-9, neural stem cell reprogramming, neuronal regeneration, retina
- MeSH Terms
- none
- PubMed
- 29239312 Full text @ Neural Regen Res
Citation
Madelaine, R., Mourrain, P. (2017) Endogenous retinal neural stem cell reprogramming for neuronal regeneration. Neural regeneration research. 12:1765-1767.
Abstract
In humans, optic nerve injuries and associated neurodegenerative diseases are often followed by permanent vision loss. Consequently, an important challenge is to develop safe and effective methods to replace retinal neurons and thereby restore neuronal functions and vision. Identifying cellular and molecular mechanisms allowing to replace damaged neurons is a major goal for basic and translational research in regenerative medicine. Contrary to mammals, the zebrafish has the capacity to fully regenerate entire parts of the nervous system, including retina. This regenerative process depends on endogenous retinal neural stem cells, the Müller glial cells. Following injury, zebrafish Müller cells go back into cell cycle to proliferate and generate new neurons, while mammalian Müller cells undergo reactive gliosis. Recently, transcription factors and microRNAs have been identified to control the formation of new neurons derived from zebrafish and mammalian Müller cells, indicating that cellular reprogramming can be an efficient strategy to regenerate human retinal neurons. Here we discuss recent insights into the use of endogenous neural stem cell reprogramming for neuronal regeneration, differences between zebrafish and mammalian Müller cells, and the need to pursue the identification and characterization of new molecular factors with an instructive and potent function in order to develop theurapeutic strategies for eye diseases.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping