ZFIN ID: ZDB-PUB-171128-23
Regeneration Genetics
Chen, C.H., Poss, K.D.
Date: 2017
Source: Annual review of genetics   51: 63-82 (Review)
Registered Authors: Chen, Chen-Hui, Poss, Kenneth D.
Keywords: blastema, genetics, imaging, regeneration, salamanders, zebrafish
MeSH Terms:
  • Animals
  • Animals, Genetically Modified
  • Bacterial Proteins/genetics
  • Bacterial Proteins/metabolism
  • Genes, Reporter
  • Genomics/methods*
  • Green Fluorescent Proteins/genetics
  • Green Fluorescent Proteins/metabolism
  • Humans
  • Luminescent Proteins/genetics
  • Luminescent Proteins/metabolism
  • Molecular Imaging/methods
  • Promoter Regions, Genetic
  • Regeneration/genetics*
  • Regenerative Medicine/methods
  • Reverse Genetics/methods*
  • Signal Transduction
  • Urodela/genetics*
  • Urodela/growth & development
  • Urodela/metabolism
  • Zebrafish/genetics*
  • Zebrafish/growth & development
  • Zebrafish/metabolism
PubMed: 28853919 Full text @ Annu. Rev. Genet.
Understanding how and why animals regenerate complex tissues has the potential to transform regenerative medicine. Here we present an overview of genetic approaches that have recently been applied to dissect mechanisms of regeneration. We describe new advances that relate to central objectives of regeneration biologists researching different tissues and species, focusing mainly on vertebrates. These objectives include defining the cellular sources and key cell behaviors in regenerating tissue, elucidating molecular triggers and brakes for regeneration, and defining the earliest events that control the presence of these molecular factors.