PUBLICATION
Lithium prevents scopolamine-induced memory impairment in zebrafish
- Authors
- Zanandrea, R., Abreu, M.S., Piato, A., Barcellos, L.J.G., Giacomini, A.C.V.V.
- ID
- ZDB-PUB-171113-9
- Date
- 2017
- Source
- Neuroscience letters 664: 34-37 (Journal)
- Registered Authors
- Keywords
- Acetylcholinesterase, Alzheimer's disease, Anxiety, Cognition, Memory
- MeSH Terms
-
- Animals
- Antidepressive Agents/pharmacology
- Antidepressive Agents/therapeutic use
- Cholinesterase Inhibitors/pharmacology
- Cholinesterase Inhibitors/therapeutic use
- Dose-Response Relationship, Drug
- Enzyme Inhibitors/pharmacology
- Enzyme Inhibitors/therapeutic use
- Female
- Lithium Carbonate/pharmacology
- Lithium Carbonate/therapeutic use*
- Male
- Maze Learning/drug effects*
- Maze Learning/physiology
- Memory Disorders/chemically induced*
- Memory Disorders/prevention & control*
- Memory Disorders/psychology
- Motor Activity/drug effects
- Motor Activity/physiology
- Muscarinic Antagonists/toxicity
- Scopolamine/toxicity*
- Zebrafish
- PubMed
- 29126775 Full text @ Neurosci. Lett.
Citation
Zanandrea, R., Abreu, M.S., Piato, A., Barcellos, L.J.G., Giacomini, A.C.V.V. (2017) Lithium prevents scopolamine-induced memory impairment in zebrafish. Neuroscience letters. 664:34-37.
Abstract
We examined whether lithium carbonate (Li2CO3, 100mg/L) is able to prevent memory impairment induced by scopolamine. Moreover, we evaluated the effects of lithium on anxiety-like behavior and acetylcholinesterase activity in adult zebrafish. We demonstrated that lithium prevents the memory impairment induced by scopolamine, decreases exploration and increases the activity of acetylcholinesterase in zebrafish. Collectively, this contributes to a better understanding of the pharmacology of lithium, its interaction with cholinergic neurotransmission, and its possible application to therapeutic treatments aimed at improving cognition.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping