PUBLICATION
Using zebrafish to model liver diseases-Where do we stand?
- Authors
- Pham, D.H., Zhang, C., Yin, C.
- ID
- ZDB-PUB-171104-4
- Date
- 2017
- Source
- Current pathobiology reports 5: 207-221 (Review)
- Registered Authors
- Yin, Chunyue
- Keywords
- Alcoholic liver disease, Cholestasis, Fibrosis, Liver regeneration, Non-alcoholic fatty liver disease, Steatosis
- MeSH Terms
- none
- PubMed
- 29098121 Full text @ Curr Pathobiol Rep
Citation
Pham, D.H., Zhang, C., Yin, C. (2017) Using zebrafish to model liver diseases-Where do we stand?. Current pathobiology reports. 5:207-221.
Abstract
Purpose of review The liver is the largest internal organ and performs both exocrine and endocrine function that is necessary for survival. Liver failure is among the leading causes of death and represents a major global health burden. Liver transplantation is the only effective treatment for end-stage liver diseases. Animal models advance our understanding of liver disease etiology and hold promise for the development of alternative therapies. Zebrafish has become an increasingly popular system for modeling liver diseases and complements the rodent models.
Recent findings The zebrafish liver contains main cell types that are found in mammalian liver and exhibits similar pathogenic responses to environmental insults and genetic mutations. Zebrafish have been used to model neonatal cholestasis, cholangiopathies, such as polycystic liver disease, alcoholic liver disease, and non-alcoholic fatty liver disease. It also provides a unique opportunity to study the plasticity of liver parenchymal cells during regeneration.
Summary In this review, we summarize the recent work of building zebrafish models of liver diseases. We highlight how these studies have brought new knowledge of disease mechanisms. We also discuss the advantages and challenges of using zebrafish to model liver diseases.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping