PUBLICATION
Developmental social isolation affects adult behavior, social interaction, and dopamine metabolite levels in zebrafish
- Authors
- Shams, S., Amlani, S., Buske, C., Chatterjee, D., Gerlai, R.
- ID
- ZDB-PUB-171102-5
- Date
- 2017
- Source
- Developmental psychobiology 60(1): 43-56 (Journal)
- Registered Authors
- Gerlai, Robert T.
- Keywords
- Zebrafish, anxiety, dopamine, locomotor activity, social behavior, social isolation
- MeSH Terms
-
- Animals
- Behavior, Animal/physiology*
- Brain/metabolism*
- Dopamine/metabolism*
- Female
- Male
- Motor Activity/physiology*
- Social Behavior*
- Social Isolation*
- Zebrafish/physiology*
- PubMed
- 29091281 Full text @ Dev Psychobiol
Citation
Shams, S., Amlani, S., Buske, C., Chatterjee, D., Gerlai, R. (2017) Developmental social isolation affects adult behavior, social interaction, and dopamine metabolite levels in zebrafish. Developmental psychobiology. 60(1):43-56.
Abstract
The zebrafish is a social vertebrate and an excellent translational model for a variety of human disorders. Abnormal social behavior is a hallmark of several human brain disorders. Social behavioral problems can arise as a result of adverse early social environment. Little is known about the effects of early social isolation in adult zebrafish. We compared zebrafish that were isolated for either short (7 days) or long duration (180 days) to socially housed zebrafish, testing their behavior across ontogenesis (ages 10, 30, 60, 90, 120, 180 days), and shoal cohesion and whole-brain monoamines and their metabolites in adulthood. Long social isolation increased locomotion and decreased shoal cohesion and anxiety in the open-field in adult. Additionally, both short and long social isolation reduced dopamine metabolite levels in response to social stimuli. Thus, early social isolation has lasting effects in zebrafish, and may be employed to generate zebrafish models of human neuropsychiatric conditions.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping