PUBLICATION
The early wound signals
- Authors
- Niethammer, P.
- ID
- ZDB-PUB-171102-12
- Date
- 2016
- Source
- Current opinion in genetics & development 40: 17-22 (Review)
- Registered Authors
- Niethammer, Philipp
- Keywords
- none
- MeSH Terms
-
- Alarmins/genetics*
- Animals
- Drosophila/genetics
- Extracellular Space/genetics
- Homeostasis/genetics
- Humans
- Phagocytes/metabolism
- Receptors, Pattern Recognition/genetics
- Wound Healing/genetics*
- Wounds and Injuries/genetics*
- Wounds and Injuries/pathology
- Zebrafish/genetics
- PubMed
- 27266971 Full text @ Curr. Opin. Genet. Dev.
Citation
Niethammer, P. (2016) The early wound signals. Current opinion in genetics & development. 40:17-22.
Abstract
Wounding of tissue barriers, such as epithelia, disrupts homeostasis and allows infection. Within minutes, animals detect injury and respond to it by recruitment of phagocytes and barrier breach closure. The signals that activate these first events are scarcely known. Commonly considered are cytoplasmic factors released into the extracellular space by lysing cells (Damage Associated Molecular Patterns, DAMPs). DAMPs activate inflammatory gene transcription through pattern recognition receptors. But the promptness of wound responses is difficult to explain by transcriptional mechanisms alone. This review highlights the emerging role of nonlytic stress signals in the rapid detection of wounds.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping