PUBLICATION
Gut feelings: Studying enteric nervous system development, function and disease in the zebrafish model system
- Authors
- Ganz, J.
- ID
- ZDB-PUB-171005-4
- Date
- 2017
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 247(2): 268-278 (Review)
- Registered Authors
- Ganz, Julia
- Keywords
- Hirschsprung disease, enteric glia, enteric neuron, enteric neuropathies, enteric progenitor cell, enteric stem cell, gut motility, neural crest
- MeSH Terms
-
- Animals
- Enteric Nervous System*/physiology
- Enteric Nervous System*/physiopathology
- Gastrointestinal Microbiome
- Gene Expression Regulation, Developmental
- Genome-Wide Association Study
- Models, Biological
- Signal Transduction
- Zebrafish*
- PubMed
- 28975691 Full text @ Dev. Dyn.
Citation
Ganz, J. (2017) Gut feelings: Studying enteric nervous system development, function and disease in the zebrafish model system. Developmental Dynamics : an official publication of the American Association of Anatomists. 247(2):268-278.
Abstract
The enteric nervous system (ENS) is the largest part of the peripheral nervous system and is entirely neural crest derived. It provides the intrinsic innervation of the gut controlling different aspects of gut function, such as motility. In this review, we will discuss key points of zebrafish ENS development, genes and signaling pathways regulating ENS development as well as contributions of the zebrafish model system to better understand ENS disorders. During their migration, enteric progenitor cells display a gradient of developmental states based on their proliferative and migratory characteristics and show spatio-temporal heterogeneity based on gene expression patterns. Many genes and signaling pathways that regulate the migration and proliferation of EPCs have been identified, but later stages of ENS development, especially steps of neuronal and glial differentiation remain poorly understood. In recent years, zebrafish have become increasingly important to test candidate genes for ENS disorders, e.g. from genome-wide association studies, to identify environmental influences on ENS development e.g. through large-scale drug screens, and to investigate the role the gut microbiota play in ENS development and disease. With its unique advantages as a model organism, zebrafish will continue to contribute to a better understanding of ENS development, function and disease. This article is protected by copyright. All rights reserved.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping