PUBLICATION
Mussel (Mytilus coruscus) Water Extract Containing Taurine Prevents LPS-Induced Inflammatory Responses in Zebrafish Model
- Authors
- Cheong, S.H., Lee, S.H., Jeon, Y.J., Lee, D.S.
- ID
- ZDB-PUB-170830-7
- Date
- 2017
- Source
- Advances in experimental medicine and biology 975: 931-942 (Journal)
- Registered Authors
- Jeon, You-Jin
- Keywords
- Anti-inflammatory, LPS treatment, Mussel (Mytilus coruscus), Taurine, Zebrafish
- MeSH Terms
-
- Animals
- Anti-Inflammatory Agents/pharmacology*
- Cell Death/drug effects
- Complex Mixtures/pharmacology
- Disease Models, Animal
- Embryo, Nonmammalian
- Inflammation*/chemically induced
- Inflammation*/metabolism
- Lipopolysaccharides/toxicity
- Mytilus/chemistry*
- Reactive Oxygen Species/metabolism
- Taurine/pharmacology*
- Zebrafish
- PubMed
- 28849512 Full text @ Adv. Exp. Med. Biol.
Citation
Cheong, S.H., Lee, S.H., Jeon, Y.J., Lee, D.S. (2017) Mussel (Mytilus coruscus) Water Extract Containing Taurine Prevents LPS-Induced Inflammatory Responses in Zebrafish Model. Advances in experimental medicine and biology. 975:931-942.
Abstract
Mussel (Mytilus coruscus) water extract had strong anti-inflammatory activities, but the effects and its mechanisms of mussel on anti-inflammatory properties in vivo remain to be determined. This study, therefore, was designed to investigate anti-inflammatory activities of mussel water extract containing a large amounts of taurine (151.96 nmol/mg) using the lipopolysaccharide (LPS)-induced inflammatory zebrafish model. In this study, mussel water extract containing taurine shows potent protective effects against the cell death stimulated by LPS exposure in zebrafish embryos. In addition, zebrafish subjected to LPS treatment exhibited significantly increased reactive oxygen species (ROS) and nitric oxide (NO) levels. However, mussel water extract markedly suppressed LPS-induced ROS and NO production. Our results indicate that mussel water extract attenuated inflammation by inhibiting the LPS-induced intracellular ROS and NO production in zebrafish embryos. These findings could demonstrate the anti-inflammatory activity of mussel water extract containing taurine, which might have a protective effects on inflammatory diseases.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping