PUBLICATION
Antioxidant Effects of Short-Neck Clam (Tapes philippinarum) Water Extract Containing Taurine Against AAPH-Induced Oxidative Stress in Zebrafish Embryos
- Authors
- Lee, D.S., Lee, S.H., Jeon, Y.J., Cheong, S.H.
- ID
- ZDB-PUB-170830-5
- Date
- 2017
- Source
- Advances in experimental medicine and biology 975: 1035-1046 (Journal)
- Registered Authors
- Jeon, You-Jin
- Keywords
- AAPH, Oxidative stress, Short-neck clam ( Tapes philippinarum ), Taurine, Zebrafish
- MeSH Terms
-
- Amidines/toxicity
- Animals
- Antioxidants/pharmacology*
- Bivalvia*/chemistry
- Complex Mixtures/pharmacology
- Embryo, Nonmammalian
- Oxidants/toxicity
- Oxidative Stress/drug effects*
- Taurine/pharmacology*
- Zebrafish
- PubMed
- 28849520 Full text @ Adv. Exp. Med. Biol.
Citation
Lee, D.S., Lee, S.H., Jeon, Y.J., Cheong, S.H. (2017) Antioxidant Effects of Short-Neck Clam (Tapes philippinarum) Water Extract Containing Taurine Against AAPH-Induced Oxidative Stress in Zebrafish Embryos. Advances in experimental medicine and biology. 975:1035-1046.
Abstract
The purpose of this study was to investigate the antioxidant activities of short-neck clam water extract (SNC-WE) enriched in taurine. In the present study, the half-maximal inhibitory concentration (IC50) values of the SNC-WE for DPPH, superoxide, and alkyl radical scavenging activities determined by an electron spin resonance (ESR) spectrometer were 3.16, 1.54 and 0.58 mg/mL, respectively. Furthermore, we evaluated the inhibitory effect of taurine enriched SNC-WE against the oxidative stress induced by 2,2'-azobis dihydrochloride (AAPH) in zebrafish embryos. In the present study, we observed that taurine enriched SNC-WE significantly suppressed reactive oxygen species (ROS) production, lipid peroxidation as well as cell death in the zebrafish model. These results indicate that taurine enriched SNC-WE might have antioxidant effects in both in vitro and in vivo zebrafish model.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping