PUBLICATION

Regulation of Translationally Repressed mRNAs in Zebrafish and Mouse Oocytes

Authors
Kotani, T., Maehata, K., Takei, N.
ID
ZDB-PUB-170806-2
Date
2017
Source
Results and problems in cell differentiation   63: 297-324 (Chapter)
Registered Authors
Kotani, Tomoya
Keywords
none
MeSH Terms
  • Animals
  • Female
  • Mice/embryology
  • Mice/genetics*
  • Oocytes/metabolism*
  • Oogenesis/genetics
  • Protein Biosynthesis*
  • RNA, Messenger, Stored/genetics*
  • Zebrafish/embryology
  • Zebrafish/genetics*
PubMed
28779323 Full text @ Results Probl. Cell Diff.
Abstract
From the beginning of oogenesis, oocytes accumulate tens of thousands of mRNAs for promoting oocyte growth and development. A large number of these mRNAs are translationally repressed and localized within the oocyte cytoplasm. Translational activation of these dormant mRNAs at specific sites and timings plays central roles in driving progression of the meiotic cell cycle, axis formation, mitotic cleavages, transcriptional initiation, and morphogenesis. Regulation of the localization and temporal translation of these mRNAs has been shown to rely on cis-acting elements in the mRNAs and trans-acting factors recognizing and binding to the elements. Recently, using model vertebrate zebrafish, localization itself and formation of physiological structures such as RNA granules have been shown to coordinate the accurate timings of translational activation of dormant mRNAs. This subcellular regulation of mRNAs is also utilized in other animals including mouse. In this chapter, we review fundamental roles of temporal regulation of mRNA translation in oogenesis and early development and then focus on the mechanisms of mRNA regulation in the oocyte cytoplasm by which the activation of dormant mRNAs at specific timings is achieved.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes