PUBLICATION
Inhibitory effect of 5-iodotubercidin on pigmentation
- Authors
- Kim, K.I., Jeong, H.B., Ro, H., Lee, J.H., Kim, C.D., Yoon, T.J.
- ID
- ZDB-PUB-170708-8
- Date
- 2017
- Source
- Biochemical and Biophysical Research Communications 490(4): 1282-1286 (Journal)
- Registered Authors
- Kim, Chang Deok, Ro, Hyunju
- Keywords
- 5-Iodotubercidin, AKT, CREB, ERK, Pigmentation, Zebrafish
- MeSH Terms
-
- Animals
- Cell Line, Tumor
- Cyclic AMP Response Element-Binding Protein/antagonists & inhibitors
- Cyclic AMP Response Element-Binding Protein/genetics
- Cyclic AMP Response Element-Binding Protein/metabolism
- Embryo, Nonmammalian/drug effects
- Enzyme Inhibitors/pharmacology*
- Gene Expression Regulation
- Humans
- Melanocytes/cytology
- Melanocytes/drug effects*
- Melanocytes/metabolism
- Microphthalmia-Associated Transcription Factor/antagonists & inhibitors
- Microphthalmia-Associated Transcription Factor/genetics
- Microphthalmia-Associated Transcription Factor/metabolism
- Mitogen-Activated Protein Kinase 1/genetics
- Mitogen-Activated Protein Kinase 1/metabolism
- Mitogen-Activated Protein Kinase 3/genetics
- Mitogen-Activated Protein Kinase 3/metabolism
- Monophenol Monooxygenase/antagonists & inhibitors
- Monophenol Monooxygenase/genetics
- Monophenol Monooxygenase/metabolism
- Phosphorylation/drug effects
- Pigmentation/drug effects*
- Pigmentation/genetics
- Proto-Oncogene Proteins c-akt/agonists
- Proto-Oncogene Proteins c-akt/genetics
- Proto-Oncogene Proteins c-akt/metabolism
- Signal Transduction
- Skin/drug effects*
- Skin/metabolism
- Skin Lightening Preparations/pharmacology*
- Trypsin/genetics
- Trypsin/metabolism
- Tubercidin/analogs & derivatives*
- Tubercidin/pharmacology
- Zebrafish
- PubMed
- 28684314 Full text @ Biochem. Biophys. Res. Commun.
Citation
Kim, K.I., Jeong, H.B., Ro, H., Lee, J.H., Kim, C.D., Yoon, T.J. (2017) Inhibitory effect of 5-iodotubercidin on pigmentation. Biochemical and Biophysical Research Communications. 490(4):1282-1286.
Abstract
Melanin pigments are the primary contributors for the skin color. They are produced in melanocytes and then transferred to keratinocytes, eventually giving various colors on skin surface. Although many depigmenting and/or skin-lightening agents have been developed, there is still a growing demand on materials for reducing pigmentation. We attempted to find materials for depigmentation and/or skin-lightening using the small molecule compounds commercially available, and found that 5-iodotubercidin had inhibitory potential on pigmentation. When HM3KO melanoma cells were treated with 5-iodotubercidin, pigmentation was dramatically reduced. The 5-iodotubercidin decreased the protein level for pigmentation-related molecules such as MITF, tyrosinase, and TRP1. In addition, 5-iodotubercidin decreased the phosphorylation of CREB, while increased the phosphorylation of AKT and ERK. These data suggest that 5-iodotubercidin inhibits melanogenesis via the regulation of intracellular signaling related with pigmentation. Finally, 5-iodotubercidin markedly inhibited the melanogenesis of zebrafish embryos, an in vivo evaluation model for pigmentation. Together, these data suggest that 5-iodotubercidin can be developed as a depigmenting and/or skin-lightening agent.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping