PUBLICATION
Genetic approaches to retinal research in zebrafish
- Authors
- Niklaus, S., Neuhauss, S.C.F.
- ID
- ZDB-PUB-170706-5
- Date
- 2017
- Source
- Journal of neurogenetics 31(3): 70-87 (Review)
- Registered Authors
- Neuhauss, Stephan
- Keywords
- Retina, forward genetics, reverse genetics, transgenesis, zebrafish
- MeSH Terms
-
- Animals
- Animals, Genetically Modified*
- Genetic Techniques*
- Retina/physiology*
- Zebrafish/anatomy & histology*
- PubMed
- 28678567 Full text @ J. Neurogenet.
Citation
Niklaus, S., Neuhauss, S.C.F. (2017) Genetic approaches to retinal research in zebrafish. Journal of neurogenetics. 31(3):70-87.
Abstract
The zebrafish (Danio rerio) possesses a vertebrate-type retina that is extraordinarily conserved in evolution. This well-organized and anatomically easily accessible part of the central nervous system has been widely investigated in zebrafish, promoting general understanding of retinal development, morphology, function and associated diseases. Over the recent years, genome and protein engineering as well as imaging techniques have experienced revolutionary advances and innovations, creating new possibilities and methods to study zebrafish development and function. In this review, we focus on some of these emerging technologies and how they may impact retinal research in the future. We place an emphasis on genetic techniques, such as transgenic approaches and the revolutionizing new possibilities in genome editing.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping