ZFIN ID: ZDB-PUB-170627-4
Advanced carbon dots via plasma-induced surface functionalization for fluorescent and bio-medical applications
Park, S.Y., Lee, C.Y., An, H.R., Kim, H., Lee, Y.C., Park, E.C., Chun, H.S., Yang, H.Y., Choi, S.H., Kim, H.S., Kang, K.S., Park, H.G., Kim, J.P., Choi, Y., Lee, J., Lee, H.U.
Date: 2017
Source: Nanoscale   9(26): 9210-9217 (Journal)
Registered Authors: Chun, Hang-Suk
Keywords: none
MeSH Terms:
  • Acinetobacter baumannii/drug effects
  • Animals
  • Anti-Bacterial Agents/chemistry
  • Carbon/chemistry*
  • Cell Line, Tumor
  • Escherichia coli/drug effects
  • Fluorescence*
  • Humans
  • Materials Testing
  • Plasma Gases*
  • Polyethylene Glycols
  • Quantum Dots/chemistry*
  • Reactive Oxygen Species/metabolism
  • Zebrafish
PubMed: 28650486 Full text @ Nanoscale
Multifunctional carbon-based nanodots (C-dots) are synthesized using atmospheric plasma treatments involving reactive gases (oxygen and nitrogen). Surface design was achieved through one-step plasma treatment of C-dots (AC-paints) from polyethylene glycol used as a precursor. These AC-paints show high fluorescence, low cytotoxicity and excellent cellular imaging capability. They exhibit bright fluorescence with a quantum yield twice of traditional C-dots. The cytotoxicity of AC-paints was tested on BEAS2B, THLE2, A549 and hep3B cell lines. The in vivo experiments further demonstrated the biocompatibility of AC-paints using zebrafish as a model, and imaging tests demonstrated that the AC-paints can be used as bio-labels (at a concentration of <5 mg mL-1). Particularly, the oxygen plasma-treated AC-paints (AC-paints-O) show antibacterial effects due to increased levels of reactive oxygen species (ROS) in AC-paints (at a concentration of >1 mg mL-1). AC-paints can effectively inhibit the growth of Escherichia coli (E. coli) and Acinetobacter baumannii (A. baumannii). Such remarkable performance of the AC-paints has important applications in the biomedical field and environmental systems.