PUBLICATION
Masking of a circadian behavior in larval zebrafish involves the thalamo-habenula pathway
- Authors
- Lin, Q., Jesuthasan, S.
- ID
- ZDB-PUB-170624-10
- Date
- 2017
- Source
- Scientific Reports 7: 4104 (Journal)
- Registered Authors
- Jesuthasan, Suresh
- Keywords
- Animal behaviour, Neural circuits
- MeSH Terms
-
- Calcium/metabolism
- Signal Transduction*/radiation effects
- Calcium Signaling/radiation effects
- Animals
- Larva
- Habenula/metabolism*
- Thalamus/metabolism*
- Zebrafish/physiology*
- Light
- Circadian Rhythm*/radiation effects
- PubMed
- 28642483 Full text @ Sci. Rep.
Citation
Lin, Q., Jesuthasan, S. (2017) Masking of a circadian behavior in larval zebrafish involves the thalamo-habenula pathway. Scientific Reports. 7:4104.
Abstract
Changes in illumination can rapidly influence behavior that is normally controlled by the circadian clock. This effect is termed masking. In mice, masking requires melanopsin-expressing retinal ganglion cells that detect blue light and project to the thalamus. It is not known whether masking is wavelength-dependent in other vertebrates, nor is it known whether the thalamus is also involved or how it influences masking. Here, we address these questions in zebrafish. We find that diel vertical migration, a circadian behavior in larval zebrafish, is effectively triggered by blue, but not by red light. Two-photon calcium imaging reveals that a thalamic nucleus and a downstream structure, the habenula, have a sustained response to blue but not to red light. Lesioning the habenula reduces light-evoked climbing. These data suggest that the thalamo-habenula pathway is involved in the ability of blue light to influence a circadian behavior.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping