PUBLICATION
Mechanosensory neurons control the timing of spinal microcircuit selection during locomotion
- Authors
- Wyart, C., Knafo, S., Fidelin, K., Prendergast, A., Tseng, P.B., Parrin, A., Dickey, C.W., Böhm, U.L., Nunes FIgueiredo, S., Thouvenin, O., Pascal-Moussellard, H.
- ID
- ZDB-PUB-170618-4
- Date
- 2017
- Source
- eLIFE 6: (Journal)
- Registered Authors
- Prendergast, Andrew, Wyart, Claire
- Keywords
- neuroscience, zebrafish
- MeSH Terms
-
- Animals
- Locomotion*
- Mechanoreceptors/physiology*
- Neural Pathways/physiology*
- Sensory Receptor Cells/physiology*
- Spinal Cord/physiology*
- Zebrafish
- PubMed
- 28623664 Full text @ Elife
Citation
Wyart, C., Knafo, S., Fidelin, K., Prendergast, A., Tseng, P.B., Parrin, A., Dickey, C.W., Böhm, U.L., Nunes FIgueiredo, S., Thouvenin, O., Pascal-Moussellard, H. (2017) Mechanosensory neurons control the timing of spinal microcircuit selection during locomotion. eLIFE. 6.
Abstract
Despite numerous physiological studies about reflexes in the spinal cord, the contribution of mechanosensory feedback to active locomotion and the nature of underlying spinal circuits remains elusive. Here we investigate how mechanosensory feedback shapes active locomotion in a genetic model organism exhibiting simple locomotion-the zebrafish larva. We show that mechanosensory feedback enhances the recruitment of motor pools during active locomotion. Furthermore, we demonstrate that inputs from mechanosensory neurons increase locomotor speed by prolonging fast swimming at the expense of slow swimming during stereotyped acoustic escape responses. This effect could be mediated by distinct mechanosensory neurons. In the spinal cord, we show that connections compatible with monosynaptic inputs from mechanosensory Rohon-Beard neurons onto ipsilateral V2a interneurons selectively recruited at high speed can contribute to the observed enhancement of speed. Altogether, our study reveals the basic principles and a circuit diagram enabling speed modulation by mechanosensory feedback in the vertebrate spinal cord.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping