PUBLICATION
Using Zebrafish to Study Pathways that Regulate Hematopoietic Stem Cell Self-Renewal and Migration
- Authors
- Choudhuri, A., Fast, E.M., Zon, L.I.
- ID
- ZDB-PUB-170608-1
- Date
- 2017
- Source
- Stem Cell Reports 8: 1465-1471 (Other)
- Registered Authors
- Zon, Leonard I.
- Keywords
- HSC, chemical screen, clonality, niche, zebrafish
- MeSH Terms
-
- Regeneration/physiology
- Cell Movement
- Hematopoietic Stem Cells/cytology*
- Hematopoietic Stem Cells/metabolism
- Zebrafish
- Signal Transduction
- Animals
- Proto-Oncogene Proteins c-myb/metabolism
- Cell Self Renewal/physiology*
- Cell Differentiation
- Platelet Membrane Glycoprotein IIb/metabolism
- Stem Cell Niche/physiology
- PubMed
- 28591648 Full text @ Stem Cell Reports
Citation
Choudhuri, A., Fast, E.M., Zon, L.I. (2017) Using Zebrafish to Study Pathways that Regulate Hematopoietic Stem Cell Self-Renewal and Migration. Stem Cell Reports. 8:1465-1471.
Abstract
This perspective describes the usefulness of zebrafish as a model to study interaction of hematopoietic stem cells with the associated niche in vivo, explains how such interactions influence regeneration, migration, and clonality of HSCs, and defines their fate during differentiation.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping