PUBLICATION
Zebrafish Models of Retinal Disease
- Authors
- Link, B.A., Collery, R.F.
- ID
- ZDB-PUB-170526-24
- Date
- 2015
- Source
- Annual review of vision science 1: 125-153 (Review)
- Registered Authors
- Keywords
- animal model, eye, genome editing, mutant, transgenic
- MeSH Terms
- none
- PubMed
- 28532376 Full text @ Annu Rev Vis Sci
Citation
Link, B.A., Collery, R.F. (2015) Zebrafish Models of Retinal Disease. Annual review of vision science. 1:125-153.
Abstract
Visual defects affect a large proportion of humanity, have a significant negative impact on quality of life, and cause significant economic burden. The wide variety of visual disorders and the large number of gene mutations responsible require a flexible animal model system to carry out research for possible causes and cures for the blinding conditions. With eyes similar to humans in structure and function, zebrafish are an important vertebrate model organism that is being used to study genetic and environmental eye diseases, including myopia, glaucoma, retinitis pigmentosa, ciliopathies, albinism, and diabetes. This review details the use of zebrafish in modeling human ocular diseases.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping