PUBLICATION
Anxiolytic-like effects of noribogaine in zebrafish
- Authors
- Kalueff, A.V., Kaluyueva, A., Mailet, E.L.
- ID
- ZDB-PUB-170510-13
- Date
- 2017
- Source
- Behavioural brain research 330: 63-67 (Journal)
- Registered Authors
- Kalueff, Allan V.
- Keywords
- anxiety, drug abuse, noribogaine, zebrafish
- MeSH Terms
-
- Animals
- Anti-Anxiety Agents/metabolism
- Anti-Anxiety Agents/pharmacology
- Anxiety/drug therapy
- Anxiety Disorders/drug therapy
- Behavior, Animal/drug effects
- Disease Models, Animal
- Female
- Hallucinogens/pharmacology
- Ibogaine/analogs & derivatives*
- Ibogaine/metabolism
- Ibogaine/pharmacology
- Locomotion/drug effects
- Male
- Stress, Physiological/drug effects*
- Zebrafish/metabolism
- Zebrafish/physiology
- PubMed
- 28479267 Full text @ Behav. Brain Res.
Citation
Kalueff, A.V., Kaluyueva, A., Mailet, E.L. (2017) Anxiolytic-like effects of noribogaine in zebrafish. Behavioural brain research. 330:63-67.
Abstract
Noribogaine is the main psychoactive metabolite of the hallucinogenic drug ibogaine, and is a particularly interesting compound potentially useful to treat dependence and various psychiatric disorders. Here, we report the effects of noribogaine on anxiety and locomotion in zebrafish (Danio rerio), a new promising model organism in neurobehavioral and psychopharmacological research. Adult zebrafish were subjected to the 5min novel tank test (NTT) following an acute, 20min drug immersion in 1, 5 and 10mg/L noribogaine. Overall, noribogaine produced robust anxiolytic-like behavior in zebrafish (increasing the time spent and transition to the top half compartment and reducing freezing bouts) without overt effects on fish locomotion. Taken together, these results indicate that noribogaine modulates the components of the acute stress response related to emotionality and anxiety behaviors, implicating this drug as a potentially useful non-sedative anxiolytic agent.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping