PUBLICATION

Friction forces position the neural anlage

Authors
Smutny, M., Ákos, Z., Grigolon, S., Shamipour, S., Ruprecht, V., Čapek, D., Behrndt, M., Papusheva, E., Tada, M., Hof, B., Vicsek, T., Salbreux, G., Heisenberg, C.P.
ID
ZDB-PUB-170328-2
Date
2017
Source
Nature cell biology   19(4): 306-317 (Journal)
Registered Authors
Behrndt, Martin, Heisenberg, Carl-Philipp, Ruprecht, Verena, Smutny, Michael, Tada, Masazumi
Keywords
none
MeSH Terms
  • Animals
  • Biomechanical Phenomena
  • Cadherins/metabolism
  • Cell Communication
  • Cell Movement
  • Embryo, Nonmammalian/cytology
  • Endoderm/cytology
  • Endoderm/embryology
  • Friction*
  • Gastrulation
  • Hydrodynamics
  • Mesoderm/cytology
  • Mesoderm/embryology
  • Models, Biological
  • Morphogenesis
  • Mutation/genetics
  • Nervous System/embryology*
  • Neural Plate/cytology
  • Neural Plate/embryology
  • Zebrafish/embryology*
  • Zebrafish Proteins/metabolism
PubMed
28346437 Full text @ Nat. Cell Biol.
Abstract
During embryonic development, mechanical forces are essential for cellular rearrangements driving tissue morphogenesis. Here, we show that in the early zebrafish embryo, friction forces are generated at the interface between anterior axial mesoderm (prechordal plate, ppl) progenitors migrating towards the animal pole and neurectoderm progenitors moving in the opposite direction towards the vegetal pole of the embryo. These friction forces lead to global rearrangement of cells within the neurectoderm and determine the position of the neural anlage. Using a combination of experiments and simulations, we show that this process depends on hydrodynamic coupling between neurectoderm and ppl as a result of E-cadherin-mediated adhesion between those tissues. Our data thus establish the emergence of friction forces at the interface between moving tissues as a critical force-generating process shaping the embryo.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping