PUBLICATION
A gene regulatory program controlling early Xenopus mesendoderm formation: network conservation and motifs
- Authors
- Charney, R.M., Paraiso, K.D., Blitz, I.L., Cho, K.W.
- ID
- ZDB-PUB-170328-11
- Date
- 2017
- Source
- Seminars in cell & developmental biology 66: 12-24 (Review)
- Registered Authors
- Blitz, Ira
- Keywords
- Xenopus, endoderm, evolutionary conservation, gene regulatory network, network motifs, transcription factors
- MeSH Terms
-
- Animals
- Cell Differentiation
- Endoderm/embryology*
- Gene Regulatory Networks/genetics*
- Transcription Factors/metabolism*
- Xenopus/genetics*
- Xenopus Proteins/genetics*
- PubMed
- 28341363 Full text @ Sem. Cell Dev. Biol.
Citation
Charney, R.M., Paraiso, K.D., Blitz, I.L., Cho, K.W. (2017) A gene regulatory program controlling early Xenopus mesendoderm formation: network conservation and motifs. Seminars in cell & developmental biology. 66:12-24.
Abstract
Germ layer formation is among the earliest differentiation events in metazoan embryos. In triploblasts, three germ layers are formed, among which the endoderm gives rise to the epithelial lining of the gut tube and associated organs including the liver, pancreas and lungs. In frogs (Xenopus), where early germ layer formation has been studied intensively, the process of endoderm specification involves the interplay of dozens of transcription factors. Here, we review the interactions between these factors, summarized in a transcriptional gene regulatory network (GRN). We highlight regulatory connections conserved between Xenopus, zebrafish, mouse, and human endodermal lineages. Especially prominent is the conserved role and regulatory targets of the Nodal signaling pathway and the T-box transcription factors, Vegt and Eomes. Additionally, we highlight some network topologies and motifs, and speculate on their possible roles in development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping