PUBLICATION
Obesity-induced decreases in muscle performance are not reversed by weight loss
- Authors
- Seebacher, F., Tallis, J., McShea, K., James, R.S.
- ID
- ZDB-PUB-170326-4
- Date
- 2017
- Source
- International journal of obesity (2005) 41(8): 1271-1278 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Animals
- Basal Metabolism/physiology
- Disease Models, Animal
- Energy Metabolism
- Motor Activity
- Muscle Contraction/physiology
- Muscle, Skeletal/metabolism
- Muscle, Skeletal/physiopathology*
- Myosin Heavy Chains/metabolism
- Obesity/metabolism
- Obesity/physiopathology*
- Physical Conditioning, Animal
- Swimming/physiology
- Weight Loss*
- Zebrafish
- PubMed
- 28337027 Full text @ Int. J. Obes. (Lond).
Citation
Seebacher, F., Tallis, J., McShea, K., James, R.S. (2017) Obesity-induced decreases in muscle performance are not reversed by weight loss. International journal of obesity (2005). 41(8):1271-1278.
Abstract
Background/objectives Obesity can affect muscle phenotypes, and may thereby constrain movement and energy expenditure. Weight loss is a common and intuitive intervention for obesity, but it is not known whether the effects of obesity on muscle function are reversible by weight loss. Here we tested whether obesity-induced changes in muscle metabolic and contractile phenotypes are reversible by weight loss.
Subjects/methods We used zebrafish (Danio rerio) in a factorial design to compare energy metabolism, locomotor capacity, muscle isometric force and work-loop power output, and myosin heavy chain composition between lean fish, diet-induced obese fish, and fish that were obese and then returned to lean body mass following diet restriction.
Results Obesity increased resting metabolic rates (P<0.001) and decreased maximal metabolic rates (P=0.030), but these changes were reversible by weight-loss, and were not associated with changes in muscle citrate synthase activity. In contrast, obesity-induced decreases in locomotor performance (P=0.0034), and isolated muscle isometric stress (P=0.01), work loop power output (P<0.001), and relaxation rates (P=0.012) were not reversed by weight loss. Similarly, obesity-induced decreases in concentrations of fast and slow myosin heavy chains, and a shift towards fast myosin heavy chains were not reversed by weight loss.
Conclusion Obesity-induced changes in locomotor performance and muscle contractile function were not reversible by weight loss. These results show that weight loss alone may not be a sufficient intervention.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping