PUBLICATION
Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells
- Authors
- Jiang, T., Kindt, K., Wu, D.K.
- ID
- ZDB-PUB-170308-6
- Date
- 2017
- Source
- eLIFE 6: (Journal)
- Registered Authors
- Kindt, Katie
- Keywords
- chicken, developmental biology, mouse, neuroscience, stem cells, zebrafish
- MeSH Terms
-
- Organogenesis
- Transcription, Genetic*
- Hair Cells, Vestibular/physiology*
- Homeodomain Proteins/metabolism*
- Animals
- Transcription Factors/metabolism*
- Ear, Inner/embryology*
- Zebrafish/embryology*
- PubMed
- 28266911 Full text @ Elife
Citation
Jiang, T., Kindt, K., Wu, D.K. (2017) Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells. eLIFE. 6.
Abstract
The asymmetric location of stereociliary bundle (hair bundle) on apical surface of mechanosensory hair cells (HCs) dictates the direction in which a given HC can respond to cues such as sound, head movements, and water pressure. Notably, vestibular sensory organs of the inner ear, the maculae, exhibit a line of polarity reversal (LPR) across which, hair bundles are polarized in a mirror-image pattern. Similarly, HCs in neuromasts of the zebrafish lateral line system are generated as pairs, and two sibling HCs develop opposite hair bundle orientations. Within these sensory organs, expression of the transcription factor Emx2 is restricted to only one side of the LPR in the maculae or one of the two sibling HCs in neuromasts. Emx2 mediates hair bundle polarity reversal in these restricted subsets of HCs and generates the mirror-image pattern of the sensory organs. Downstream effectors of Emx2 control bundle polarity cell-autonomously via heterotrimeric G proteins.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping