PUBLICATION

Cellular responses to recurrent pentylenetetrazole-induced seizures in the adult zebrafish brain

Authors
Duy, P.Q., Berberoglu, M.A., Beattie, C.E., Hall, C.W.
ID
ZDB-PUB-170228-4
Date
2017
Source
Neuroscience   349: 118-127 (Journal)
Registered Authors
Beattie, Christine, Berberoglu, Michael
Keywords
Epilepsy, neurogenesis, seizures, zebrafish
MeSH Terms
  • Animals
  • Behavior, Animal
  • Brain/drug effects*
  • Brain/physiopathology
  • Convulsants/pharmacology*
  • Disease Models, Animal
  • Epilepsy/chemically induced
  • Motor Activity/drug effects
  • Motor Activity/physiology
  • Pentylenetetrazole/pharmacology*
  • Seizures/chemically induced
  • Seizures/physiopathology*
  • Zebrafish
PubMed
28238851 Full text @ Neuroscience
Abstract
A seizure is a sustained increase in brain electrical activity that can result in loss of consciousness and injury. Understanding how the brain responds to seizures is important for development of new treatment strategies for epilepsy, a neurological condition characterized by recurrent and unprovoked seizures. Pharmacological induction of seizures in rodent models results in a myriad of cellular alterations, including inflammation, angiogenesis, and adult neurogenesis. The purpose of this study is to investigate the cellular responses to recurrent pentylenetetrazole seizures in the adult zebrafish brain. We subjected zebrafish to five once-daily pentylenetetrazole induced seizures and characterized the cellular consequences of these seizures. In response to recurrent seizures, we found histologic evidence of vasodilatation, perivascular leukocyte egress and leukocyte proliferation suggesting seizure-induced acute CNS inflammation. We also found evidence of increased proliferation, neurogenesis, and reactive gliosis. Collectively, our results suggest that the cellular responses to seizures in the adult zebrafish brain are similar to those observed in mammalian brains.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes