PUBLICATION
Zebrafish models in neuropsychopharmacology and CNS drug discovery
- Authors
- Khan, K.M., Collier, A.D., Meshalkina, D.A., Kysil, E.V., Khatsko, S.L., Kolesnikova, T., Morzherin, Y.Y., Warnick, J.E., Kalueff, A.V., Echevarria, D.J.
- ID
- ZDB-PUB-170222-11
- Date
- 2017
- Source
- British journal of pharmacology 174(13): 1925-1944 (Review)
- Registered Authors
- Kalueff, Allan V.
- Keywords
- Behavioral models, Genetic Models, Model organism, Preclinical study, Toxicology models, Zebrafish
- MeSH Terms
-
- Animals
- Central Nervous System Agents/chemical synthesis
- Central Nervous System Agents/chemistry
- Central Nervous System Agents/therapeutic use*
- Central Nervous System Diseases/drug therapy*
- Disease Models, Animal*
- Drug Discovery*
- Drug Evaluation, Preclinical
- Small Molecule Libraries/chemical synthesis
- Small Molecule Libraries/chemistry
- Small Molecule Libraries/therapeutic use*
- Zebrafish
- PubMed
- 28217866 Full text @ Br. J. Pharmacol.
Citation
Khan, K.M., Collier, A.D., Meshalkina, D.A., Kysil, E.V., Khatsko, S.L., Kolesnikova, T., Morzherin, Y.Y., Warnick, J.E., Kalueff, A.V., Echevarria, D.J. (2017) Zebrafish models in neuropsychopharmacology and CNS drug discovery. British journal of pharmacology. 174(13):1925-1944.
Abstract
Despite high prevalence of neuropsychiatric disorders, their etiology and molecular mechanisms remain poorly understood. The zebrafish (Danio rerio) is increasingly utilized as a powerful animal model in neuropharmacology research and in-vivo drug screening. Collectively, this makes zebrafish a useful tool for drug discovery and the identification of disordered molecular pathways. Here, we discuss zebrafish models of selected human neuropsychiatric disorders and drug-induced phenotypes. Covering a broad range of brain disorders (from anxiety and psychoses to neurodegeneration), we also summarize recent developments in zebrafish genetics and small molecule screening, which markedly enhance the disease modeling and the discovery of novel drug targets.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping