PUBLICATION
A near-infrared-emitting fluorescent probe for monitoring mitochondrial pH
- Authors
- Li, P., Xiao, H., Cheng, Y., Zhang, W., Huang, F., Zhang, W., Wang, H., Tang, B.
- ID
- ZDB-PUB-170214-330
- Date
- 2014
- Source
- Chemical communications (Cambridge, England) 50: 7184-7 (Journal)
- Registered Authors
- Wang, Hui
- Keywords
- none
- MeSH Terms
-
- Aniline Compounds/chemistry
- Aniline Compounds/pharmacology*
- Animals
- Fluorescent Dyes/chemistry
- Fluorescent Dyes/pharmacology*
- Hep G2 Cells
- Humans
- Hydrogen-Ion Concentration
- Indoles/chemistry
- Indoles/pharmacology*
- Lipopolysaccharides
- Mice
- Microscopy, Confocal
- Mitochondria/chemistry
- Mitochondria/metabolism*
- Optical Imaging
- Peritonitis/chemically induced
- Peritonitis/metabolism
- Spectrometry, Fluorescence
- Zebrafish
- PubMed
- 24866830 Full text @ Chem. Commun. (Camb.)
Citation
Li, P., Xiao, H., Cheng, Y., Zhang, W., Huang, F., Zhang, W., Wang, H., Tang, B. (2014) A near-infrared-emitting fluorescent probe for monitoring mitochondrial pH. Chemical communications (Cambridge, England). 50:7184-7.
Abstract
We demonstrate a new small molecule fluorescent probe, possessing near-infrared (NIR) emission and an unusually large Stokes shift. It can be readily taken up by live cells and mitochondria, and track subtle pH changes with effectively reduced biological background fluorescence and improved measurement accuracy.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping