PUBLICATION

IBD. Fishing for missing heritability in IBD

Authors
Pack, M.
ID
ZDB-PUB-170214-188
Date
2015
Source
Nature reviews. Gastroenterology & hepatology   12: 318-20 (Review)
Registered Authors
Pack, Michael
Keywords
Experimental models of disease, Inflammatory bowel disease, Pathogenesis
MeSH Terms
  • Animals
  • DNA Methylation*
  • Epigenesis, Genetic/physiology*
  • Inflammatory Bowel Diseases/metabolism*
  • Intestinal Mucosa/embryology*
  • Zebrafish/embryology*
PubMed
25942704 Full text @ Nat Rev Gastroenterol Hepatol
Citation
Pack, M. (2015) IBD. Fishing for missing heritability in IBD. Nature reviews. Gastroenterology & hepatology. 12:318-20.
Abstract
A genetic predisposition to IBD is widely accepted; however IBD heritability is dependent on more than the simple additive risk of genetic variants. In a new study using zebrafish, convincing evidence is presented that alterations in the epigenetic regulation of TNF might contribute to the "missing heritability" of IBD.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
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