PUBLICATION
Temporally coordinated signals progressively pattern the anteroposterior and dorsoventral body axes
- Authors
- Tuazon, F.B., Mullins, M.C.
- ID
- ZDB-PUB-170214-159
- Date
- 2015
- Source
- Seminars in cell & developmental biology 42: 118-33 (Review)
- Registered Authors
- Mullins, Mary C.
- Keywords
- BMP, FGF, Gastrulation, Morphogens, Nodal, Wnt
- MeSH Terms
-
- Animals
- Body Patterning*
- Signal Transduction*
- Vertebrates/embryology*
- Vertebrates/metabolism
- Xenopus/embryology
- Xenopus/metabolism
- Zebrafish/embryology
- Zebrafish/metabolism
- PubMed
- 26123688 Full text @ Sem. Cell Dev. Biol.
Citation
Tuazon, F.B., Mullins, M.C. (2015) Temporally coordinated signals progressively pattern the anteroposterior and dorsoventral body axes. Seminars in cell & developmental biology. 42:118-33.
Abstract
The vertebrate body plan is established through the precise spatiotemporal coordination of morphogen signaling pathways that pattern the anteroposterior (AP) and dorsoventral (DV) axes. Patterning along the AP axis is directed by posteriorizing signals Wnt, fibroblast growth factor (FGF), Nodal, and retinoic acid (RA), while patterning along the DV axis is directed by bone morphogenetic proteins (BMP) ventralizing signals. This review addresses the current understanding of how Wnt, FGF, RA and BMP pattern distinct AP and DV cell fates during early development and how their signaling mechanisms are coordinated to concomitantly pattern AP and DV tissues.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping