PUBLICATION
From bench to patient: model systems in drug discovery
- Authors
- Breyer, M.D., Look, A.T., Cifra, A.
- ID
- ZDB-PUB-170214-103
- Date
- 2015
- Source
- Disease models & mechanisms 8: 1171-4 (Other)
- Registered Authors
- Look, A. Thomas
- Keywords
- none
- MeSH Terms
-
- Animals
- Disease Models, Animal
- Drug Discovery*
- Genetic Engineering
- Humans
- Mice
- Models, Biological*
- Translational Research, Biomedical*
- Zebrafish
- PubMed
- 26438689 Full text @ Dis. Model. Mech.
Citation
Breyer, M.D., Look, A.T., Cifra, A. (2015) From bench to patient: model systems in drug discovery. Disease models & mechanisms. 8:1171-4.
Abstract
Model systems, including laboratory animals, microorganisms, and cell- and tissue-based systems, are central to the discovery and development of new and better drugs for the treatment of human disease. In this issue, Disease Models & Mechanisms launches a Special Collection that illustrates the contribution of model systems to drug discovery and optimisation across multiple disease areas. This collection includes reviews, Editorials, interviews with leading scientists with a foot in both academia and industry, and original research articles reporting new and important insights into disease therapeutics. This Editorial provides a summary of the collection's current contents, highlighting the impact of multiple model systems in moving new discoveries from the laboratory bench to the patients' bedsides.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping