ZFIN ID: ZDB-PUB-170129-5
Chemical screening in zebrafish for novel biological and therapeutic discovery
Wiley, D.S., Redfield, S.E., Zon, L.I.
Date: 2017
Source: Methods in cell biology   138: 651-679 (Chapter)
Registered Authors: Zon, Leonard I.
Keywords: Chemical, Chemoinformatic, Hit, Libraries, Phenotype, Screen, Zebrafish
MeSH Terms:
  • Animals
  • Drug Discovery/methods*
  • Drug Evaluation, Preclinical/methods*
  • Embryo, Nonmammalian/drug effects
  • High-Throughput Screening Assays/methods*
  • Humans
  • Small Molecule Libraries/pharmacology
  • Zebrafish/genetics
  • Zebrafish/growth & development*
PubMed: 28129862 Full text @ Meth. Cell. Biol.
Zebrafish chemical screening allows for an in vivo assessment of small molecule modulation of biological processes. Compound toxicities, chemical alterations by metabolism, pharmacokinetic and pharmacodynamic properties, and modulation of cell niches can be studied with this method. Furthermore, zebrafish screening is straightforward and cost effective. Zebrafish provide an invaluable platform for novel therapeutic discovery through chemical screening.