ZFIN ID: ZDB-PUB-170129-11
Zebrafish as a model for von Hippel Lindau and hypoxia-inducible factor signaling
Kim, H.R., Greenald, D., Vettori, A., Markham, E., Santhakumar, K., Argenton, F., van Eeden, F.
Date: 2017
Source: Methods in cell biology   138: 497-523 (Chapter)
Registered Authors: Argenton, Francesco, Santhakumar, Kiran, van Eeden, Freek, Vettori, Andrea
Keywords: Angiogenesis, Cancer, Circadian clock, HIF reporter, Hypoxia, Hypoxia responsive element, Hypoxia-inducible factor, Metabolism, Oxygen, Polycythemia, Prolyl hydroxylase, Zebrafish, von Hippel Lindau
MeSH Terms:
  • Animals
  • Disease Models, Animal
  • Humans
  • Hypoxia-Inducible Factor 1/genetics*
  • Oxygen/metabolism
  • Signal Transduction/genetics
  • Tumor Suppressor Proteins/genetics*
  • Tumor Suppressor Proteins/metabolism
  • Zebrafish/genetics
  • Zebrafish Proteins/genetics*
  • von Hippel-Lindau Disease/genetics*
  • von Hippel-Lindau Disease/pathology
PubMed: 28129856 Full text @ Meth. Cell. Biol.
Oxygen is a central molecule in the development of multicellular life, allowing efficient energy generation. Inadequate oxygen supply requires rapid adaptations to prevent cellular damage and the hypoxia-inducible factor (HIF) pathway plays a central role in this adaptation. Numerous diseases and disease processes are influenced by hypoxia and the HIF pathway. One component, von Hippel Lindau (VHL), is a well-known tumor suppressor, which acts at least in part via regulating HIF signaling. The zebrafish has become a central vertebrate model organism in which developmental and disease processes can be studied. In this review, we have tried to bring together knowledge on the HIF/hypoxic signaling pathway in zebrafish, including what is known on VHL functions.