PUBLICATION
Zebrafish as a model for von Hippel Lindau and hypoxia-inducible factor signaling
- Authors
- Kim, H.R., Greenald, D., Vettori, A., Markham, E., Santhakumar, K., Argenton, F., van Eeden, F.
- ID
- ZDB-PUB-170129-11
- Date
- 2017
- Source
- Methods in cell biology 138: 497-523 (Chapter)
- Registered Authors
- Argenton, Francesco, Santhakumar, Kiran, van Eeden, Freek, Vettori, Andrea
- Keywords
- Angiogenesis, Cancer, Circadian clock, HIF reporter, Hypoxia, Hypoxia responsive element, Hypoxia-inducible factor, Metabolism, Oxygen, Polycythemia, Prolyl hydroxylase, Zebrafish, von Hippel Lindau
- MeSH Terms
-
- Animals
- Disease Models, Animal
- Humans
- Hypoxia-Inducible Factor 1/genetics*
- Oxygen/metabolism
- Signal Transduction/genetics
- Tumor Suppressor Proteins/genetics*
- Tumor Suppressor Proteins/metabolism
- Zebrafish/genetics
- Zebrafish Proteins/genetics*
- von Hippel-Lindau Disease/genetics*
- von Hippel-Lindau Disease/pathology
- PubMed
- 28129856 Full text @ Meth. Cell. Biol.
Citation
Kim, H.R., Greenald, D., Vettori, A., Markham, E., Santhakumar, K., Argenton, F., van Eeden, F. (2017) Zebrafish as a model for von Hippel Lindau and hypoxia-inducible factor signaling. Methods in cell biology. 138:497-523.
Abstract
Oxygen is a central molecule in the development of multicellular life, allowing efficient energy generation. Inadequate oxygen supply requires rapid adaptations to prevent cellular damage and the hypoxia-inducible factor (HIF) pathway plays a central role in this adaptation. Numerous diseases and disease processes are influenced by hypoxia and the HIF pathway. One component, von Hippel Lindau (VHL), is a well-known tumor suppressor, which acts at least in part via regulating HIF signaling. The zebrafish has become a central vertebrate model organism in which developmental and disease processes can be studied. In this review, we have tried to bring together knowledge on the HIF/hypoxic signaling pathway in zebrafish, including what is known on VHL functions.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping